TERT-BUTYL PIPERIDIN-3-YLCARBAMATE
3-N-Boc-aminopiperidine
CAS: 172603-05-3
Molecular Formula: C10H20N2O2
TERT-BUTYL PIPERIDIN-3-YLCARBAMATE - Names and Identifiers
| Name | 3-N-Boc-aminopiperidine |
| Synonyms | 3-N-Boc-aminopiperidine 3-(Boc-Amino)piperidine 3-N-BOC-AMINO PIPERIDINE TERT-BUTYL PIPERIDIN-3-YLCARBAMATE tert-butyl N-(3-piperidinyl)carbamate 3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER CARBAMIC ACID, 3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER Carbamic acid, 3-piperidinyl-, 1,1-dimethylethyl ester (9CI) |
| CAS | 172603-05-3 |
| EINECS | 676-009-4 |
| InChI | InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-8-5-4-6-11-7-8/h8,11H,4-7H2,1-3H3,(H,12,13) |
TERT-BUTYL PIPERIDIN-3-YLCARBAMATE - Physico-chemical Properties
| Molecular Formula | C10H20N2O2 |
| Molar Mass | 200.28 |
| Density | 1.02±0.1 g/cm3(Predicted) |
| Melting Point | 102-108°C |
| Boling Point | 304.8±31.0 °C(Predicted) |
| Flash Point | 138.2°C |
| Solubility | DMSO, Methanol |
| Vapor Presure | 0.000854mmHg at 25°C |
| Appearance | Bright yellow solid |
| Color | White |
| pKa | 12.37±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.479 |
| MDL | MFCD03839941 |
TERT-BUTYL PIPERIDIN-3-YLCARBAMATE - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
TERT-BUTYL PIPERIDIN-3-YLCARBAMATE - Introduction
3-N-Boc-aminopiperidine is an organic compound with the chemical formula C12H20N2O2. The following is its nature, use, preparation and safety information:
Nature:
3-N-Boc-aminopiperidine is a colorless to light yellow crystalline solid. It is soluble in many organic solvents, such as ethanol, chloroform and dichloromethane, but poorly soluble in water. Its melting point is about 100 ° C.
Use:
The compound is mainly used as a pharmaceutical intermediate, especially for the synthesis of antibacterial drugs. It can be added to certain drug molecules as a building unit to enhance their activity and bioavailability.
Method:
The preparation of 3-N-Boc-aminopiperidine is usually obtained by The transesterification reaction of amino piperidine with tert-butyl chloroformate. In the reaction, aminopiperidine is reacted with tert-butyl chloroformate in the presence of a base to produce 3-N-Boc-aminopiperidine.
Safety Information:
Regarding the safety of 3-N-Boc-aminopiperidine, the following matters need to be noted:
-It is a chemical and should be used in a specialized laboratory or under appropriate safety measures.
-Avoid inhalation of dust, contact with skin and eyes.
-Wear appropriate personal protective equipment such as gloves, goggles and masks when used.
-In case of accidental contact, immediately flush the affected area with plenty of water and seek medical help.
-During storage, it should be kept in a dry, cool, ventilated place, away from fire and oxidizing agents.
As a chemical, any use should be accompanied by a detailed understanding of its safety data sheet and follow the relevant chemical laboratory safety practices.
Nature:
3-N-Boc-aminopiperidine is a colorless to light yellow crystalline solid. It is soluble in many organic solvents, such as ethanol, chloroform and dichloromethane, but poorly soluble in water. Its melting point is about 100 ° C.
Use:
The compound is mainly used as a pharmaceutical intermediate, especially for the synthesis of antibacterial drugs. It can be added to certain drug molecules as a building unit to enhance their activity and bioavailability.
Method:
The preparation of 3-N-Boc-aminopiperidine is usually obtained by The transesterification reaction of amino piperidine with tert-butyl chloroformate. In the reaction, aminopiperidine is reacted with tert-butyl chloroformate in the presence of a base to produce 3-N-Boc-aminopiperidine.
Safety Information:
Regarding the safety of 3-N-Boc-aminopiperidine, the following matters need to be noted:
-It is a chemical and should be used in a specialized laboratory or under appropriate safety measures.
-Avoid inhalation of dust, contact with skin and eyes.
-Wear appropriate personal protective equipment such as gloves, goggles and masks when used.
-In case of accidental contact, immediately flush the affected area with plenty of water and seek medical help.
-During storage, it should be kept in a dry, cool, ventilated place, away from fire and oxidizing agents.
As a chemical, any use should be accompanied by a detailed understanding of its safety data sheet and follow the relevant chemical laboratory safety practices.
Last Update：2024-04-09 19:05:47
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